NEPTUNE BarriersTips ,10 ul Low Retentio 

To Order Contact us: stephen@expresspharmapulse.com

Cyanine3.5 azide, 500 uL, 10 mM/DMSO
32030	Lumiprobe	500 µl	EUR 218.4

Cyanine7 azide, 500 uL, 10 mM/DMSO
35030	Lumiprobe	500 µl	EUR 218.4

Cyanine7.5 azide, 500 uL, 10 mM/DMSO
36030	Lumiprobe	500 µl	EUR 218.4

Cyanine5.5 azide, 500 uL, 10 mM/DMSO
34030	Lumiprobe	500 µl	EUR 218.4

Cyanine3 azide, 100 uL, 10 mM/DMSO
11030	Lumiprobe	10 mM/DMSO	EUR 129.6

Cyanine5 azide, 500 uL, 10 mM/DMSO
33030	Lumiprobe	500 µl	EUR 218.4

Cyanine7 azide, 100 uL, 10 mM/DMSO
15030	Lumiprobe	100 µl	EUR 129.6

Cyanine7.5 azide, 100 uL, 10 mM/DMSO
16030	Lumiprobe	100 µl	EUR 129.6

Cyanine3.5 azide, 100 uL, 10 mM/DMSO
12030	Lumiprobe	100 µl	EUR 129.6

Cyanine5 azide, 100 uL, 10 mM/DMSO
13030	Lumiprobe	100 µl	EUR 129.6

Exo I 10 U Ul 5000 Units
E70073X	Scientific Laboratory Supplies	EACH	EUR 565.44

Calibrated Streakers 10 ul 4mm with handles
ARG1394	Scientific Laboratory Supplies	PK5	EUR 356.82

Tip 0.1 - 10 uL MicroReach long universal
DD037660A	Scientific Laboratory Supplies	PK960	EUR 47.77

Economical tip 0.5 - 10 uL for micropipettes
DD391453	Scientific Laboratory Supplies	PK500	EUR 1271.1

Micropipette Acura 835 1-10 uL Socorex
DD61113	Scientific Laboratory Supplies	EACH	EUR 339.72

Corning 10-100 Ul Lambda Plus Si
4073	Scientific Laboratory Supplies	EACH	EUR 209.76

Neptune Blocking Buffer-BB2
KF17338	Neuromics	500 ml	EUR 292.8

Neptune Assay Diluent-AD3
KF17349	Neuromics	500 ml	EUR 292.8

Neptune Sample Diluent-SD3
KF17354	Neuromics	500 ml	EUR 292.8

Filter tip NEPTUNE BT10E
DD713002	Scientific Laboratory Supplies	PK960	EUR 116.28

Neptune 10ul barrier tip
BT10	Biotix	10 trays of 96 / pack	EUR 70.8
Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface

Neptune 100ul barrier tip
BT100	Biotix	10 trays of 96 / pack	EUR 70.8
Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface

Neptune 1000ul barrier tip
BT1000.96	Biotix	8 trays of 96 / pack	EUR 70.8
Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface

Neptune 20ul barrier tip
BT20	Biotix	10 trays of 96 / pack	EUR 70.8
Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface

Neptune 200ul barrier tip
BT200	Biotix	10 trays of 96 / pack	EUR 70.8
Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface

Neptune 300ul barrier tip
BT300	Biotix	10 trays of 96 / pack	EUR 70.8
Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface

E1-ClipTip 1-ch 10-300 ul BT
PIP0524	Scientific Laboratory Supplies	EACH	EUR 1248.3

E1-ClipTip 8-ch 10-300 ul BT
PIP0532	Scientific Laboratory Supplies	EACH	EUR 2020.08

1 uL Inoculating Needle White Sterile 10/BG
ARG1350	Scientific Laboratory Supplies	PK1000	EUR 214.32

1 uL Inoculating Loop Blue Sterile 10/BG
ARG1354	Scientific Laboratory Supplies	PK1000	EUR 214.32

10 uL Inoculating Loop Yellow Sterile 25/BG
ARG1356	Scientific Laboratory Supplies	PK1000	EUR 270.18

10 uL Inoculating Loop Yellow Sterile Ind. Wrapped
ARG1364	Scientific Laboratory Supplies	PK250	EUR 79.8

Albumin-X, Albumin (multiple species) removal kit (sufficient to remove 2-3 mg albumin or process ~50-100 ul serum; 10 mini-columns ~250 ul resin)
700-300-10	Alpha Diagnostics	1 kit	EUR 343.2

Neptune 1000-1250ul barrier tip
BT1250	Biotix	8 trays of 96 / pack	EUR 70.8
Description: Extended Length, Low retention, Racked, Pre-Sterile, Sample Saving Surface

Suez neptune NCP 8 Cartridge
WAT3262	Scientific Laboratory Supplies	EACH	EUR 451.44

1730 10 SNAP-SEAL 10 OZ
1730-10	CORNING	100/pk	EUR 96
Description: Disposable Plastic; Plastic Containers

99445-10 DCT 10 X 75MM
99445-10	CORNING	250/pk	EUR 75.6
Description: Disposable Culture Tubes; DCT's, CGW

GSA 10
B5767-10	ApexBio	10 mg	EUR 274.8

SC-10
B6299-10	ApexBio	10 mg	EUR 255.6

MRT 10
B7685-10	ApexBio	10 mg	EUR 285.6

TAMRA azide, 5-isomer, 500 uL, 10 mM/DMSO
37130	Lumiprobe	500 µl	EUR 218.4

R6G azide, 5-isomer, 500 uL, 10 mM/DMSO
34430	Lumiprobe	500 µl	EUR 218.4

FAM azide, 6-isomer, 500 uL, 10 mM/DMSO
35130	Lumiprobe	500 ul	EUR 103.2

FAM azide, 5-isomer, 500 uL, 10 mM/DMSO
34130	Lumiprobe	500 ul	EUR 103.2

ROX azide, 5- isomer, 100 uL, 10 mM/DMSO
11230	Lumiprobe	100 µl	EUR 129.6

TAMRA azide, 5-isomer, 100 uL, 10 mM/DMSO
17130	Lumiprobe	100 µl	EUR 129.6

ROX azide, 5- isomer, 500 uL, 10 mM/DMSO
31230	Lumiprobe	500 µl	EUR 218.4

FAM azide, 5-isomer, 100 uL, 10 mM/DMSO
14130	Lumiprobe	100 ul	EUR 90

R6G azide, 5-isomer, 100 uL, 10 mM/DMSO
14430	Lumiprobe	100 µl	EUR 129.6

FAM azide, 6-isomer, 100 uL, 10 mM/DMSO
15130	Lumiprobe	100 ul	EUR 90

E1-ClipTip Equalizer 8-ch 10-300 ul BT
PIP0560	Scientific Laboratory Supplies	EACH	EUR 2708.64

Empty boxes for ClearLine 10-200 uL racked tips
DD713120	Scientific Laboratory Supplies	PK10	EUR 54.72

Transport container 10 l low form
DD391043	Scientific Laboratory Supplies	EACH	EUR 26.22

Albumin-X, Albumin (multiple species) removal kit (sufficient to remove 6-10 mg albumin or process ~200-300 ul serum; 10 mini-columns ~1.25 ml resin)
700-1250-10	Alpha Diagnostics	1 kit	EUR 634.8

AI-10-49
A8694-10	ApexBio	10 mg	EUR 254.4
Description: AI-10-49 is a selective inhibitor of CBF? -SMMHC and RUNX1 interaction with a FRET IC50 value of 260nM. AI-10-49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice.

Keratin 10 antibody
10-2541	Fitzgerald	250 ug	EUR 590.4
Description: Mouse monoclonal Keratin 10 antibody

MFZ 10-7
B5595-10	ApexBio	10 mg	EUR 420

TC ASK 10
B5728-10	ApexBio	10 mg	EUR 525.6

PSB 10 hydrochloride
B6923-10	ApexBio	10 mg	EUR 439.2

10-DEBC hydrochloride
B7105-10	ApexBio	10 mg	EUR 265.2
Description: 10-DEBC hydrochloride is a selective inhibitor of Akt (or termed PKB) [1], with an IC50 value of approximate 48 ?M [2].Akt is a type of serine/threonine kinase. It phosphorylates and inactivates components in the apoptotic machinery, including Caspase 9 and BAD.

KinaSorb™ 10
KE785-10	Biotech Support Group	10 preps	EUR 553.2

Empty Tubes (10)
2MLET-10	BioAssay Systems	10	EUR 17
Description: Empty tubes used for preparation of urine samples for use with the Oxalate Quick Test Strips. Quantity: 10 empty 2mL tubes.

Neptune 10ul extended length barrier tip
BT10XLS3	Biotix	10 trays of 96 / pack	EUR 70.8
Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface

ClearLine 10 uL graduated tips reload system (length : 31.24 mm)
DD713128	Scientific Laboratory Supplies	PK960	EUR 44.46

Chitosan (10 cps), very low molecular weight
GP5480-100G	Glentham Life Sciences	100 g	EUR 93.6

Chitosan (10 cps), very low molecular weight
GP5480-1KG	Glentham Life Sciences	1 kg	EUR 217.2

Chitosan (10 cps), very low molecular weight
GP5480-250G	Glentham Life Sciences	250 g	EUR 122.4

Chitosan (10 cps), very low molecular weight
GP5480-25G	Glentham Life Sciences	25 g	EUR 60

Chitosan (10 cps), very low molecular weight
GP5480-500G	Glentham Life Sciences	500 g	EUR 160.8

10 XL Non-Sterile Low Retention Tips
SLS5232	Scientific Laboratory Supplies	PK1000	EUR 21.2

Inoculator 1 uL
DD42825	Scientific Laboratory Supplies	PK2000	EUR 117.42

Inoculator 1 uL
DD42828	Scientific Laboratory Supplies	PK2000	EUR 117.42

100 uL Syringe
MLCP-100muSYR-1	MiTeGen	100 uL	EUR 70
Description: 100 uL Syringe

250 uL Syringe
MLCP-250muSYR-1	MiTeGen	250 uL	EUR 73
Description: 250 uL Syringe

HG-10-102-01
B1262-10	ApexBio	10 mg	EUR 363.6
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

Ro 10-5824 dihydrochloride
B7019-10	ApexBio	10 mg	EUR 320.4

Individual Reaction Mix 10
G065-10	ABM	200 reactions	EUR 200.4

C-10, murine recombinant
4008-10	Biovision	each	EUR 307.2

IL-10, human recombinant
4155-10	Biovision	each	EUR 294

IL-10, murine recombinant
4156-10	Biovision	each	EUR 294

IL-10, rat recombinant
4157-10	Biovision	each	EUR 360

TW-47-10 with 11 in. Canisters (10)
TW-47-10	MiTeGen	1 Unit	EUR 1908
Description: TW-47-10 with 11 in. Canisters (10)

7078D 10 PIPET 10ML STERILE
7078D-10	CORNING	25/pk	EUR 310.8
Description: Disposable Pipets; Disposable Pipets, Serological, Misc

Beta-Lipotropin (1-10), porcine
A1014-10	ApexBio	10 mg	EUR 199.2
Description: Morphine-like substances exist in brain or the pituitary of various species. Beta-lipotropin (beta-LPH) was found to contain within its C-terminal sequence the primary structure of these peptides.

Amyloid ?-Peptide (10-20) (human)
A1038-10	ApexBio	10 mg	EUR 756
Description: The amyloid ?-peptide (A?) has a central role in initiating neurodegeneration in Alzheimer disease (AD) 1. It is widely believed to be an incidental catabolic byproduct of the amyloid ? protein precursor (APP) with no normal physiological function.

Amyloid ?-peptide (10-35), amide
A1102-10	ApexBio	10 mg	EUR 547.2
Description: Amyloid ?-protein (10-35) was used as a trunCated peptide model for the full-length amyloid ?-proteins (1-40) and (1-42) in high-resolution structural studies. In contrast to the full-length amyloid ?-proteins, amyloid ?-protein (10-35) allowed the contro

[bAla8]-Neurokinin A(4-10)
B6813-10	ApexBio	10 mg	EUR 1774.8

(10) Base holders and cases
BH-10	MiTeGen	10 BOX	EUR 124
Description: (10) Base holders and cases

BSA (10% in H?O)
2119-10	Biovision	each	EUR 164.4

Optifit Tip 10-1000uL Single Tray Low Retention
PIP2138	Scientific Laboratory Supplies	PK960	EUR 82.08

Low pI Kit pH 2.5-6.5 10 vials
17047201	Scientific Laboratory Supplies	EACH	EUR 330.6

mLINE pipette multipack - 3 mLINE 20 pipettes (2-20 uL 20-200 uL 100-1000 uL)
DD725662	Scientific Laboratory Supplies	EACH	EUR 894.9

RNase H, 5u/ul
BEN0202	Bio Basic	500U	EUR 199.2

Endonuclease IV, 2u/ul
BEN0591	Bio Basic	100U	EUR 146.14

RNase I, 10u/ul
BEN0601	Bio Basic	1KU	EUR 319.26

200 ul Pipet Tips
GR238007	Genorise Scientific	Pack of 24	EUR 116.4

300 ul Pipet Tips
GR238018	Genorise Scientific	Pack of 960	EUR 102

Human IP-10 ELISPOT antibody pair
CT470-10	U-CyTech	10-plate	EUR 633.6

Monkey IP-10 ELISA antibody pair
CT555-10	U-CyTech	10-plate	EUR 656.4

Human IP-10 ELISA antibody pair
CT572-10	U-CyTech	10-plate	EUR 656.4

Monkey IL-10 ELISPOT antibody pair
CT615-10	U-CyTech	10-plate	EUR 633.6

Human IL-10 ELISPOT antibody pair
CT645-10	U-CyTech	10-plate	EUR 633.6

Mouse IL-10 ELISPOT antibody pair
CT658-10	U-CyTech	10-plate	EUR 633.6

Monkey IL-10 ELISA antibody pair
CT715-10	U-CyTech	10-plate	EUR 656.4

Human IL-10 ELISA antibody pair
CT745-10	U-CyTech	10-plate	EUR 656.4

Mouse IL-10 ELISA antibody pair
CT765-10	U-CyTech	10-plate	EUR 656.4

Atholate™, protein hydrolysate, 10 kg
0134-10	AthenaES	10 kg	EUR 2378.4

Ethyl-β-D-glucuronide, 10 mg
0901-10	AthenaES	10 mg	EUR 664.8

Ethyl sulfate, sodium salt, 10 mg
0902-10	AthenaES	10 mg	EUR 158.4

Propyl-β-D-glucuronide, 10 mg
0903-10	AthenaES	10 mg	EUR 664.8

Human CellExp? IL-10, Human Recombinant
6466-10	Biovision	each	EUR 411.6

MIP-1?/CCL9/10, murine recombinant
7174-10	Biovision	each	EUR 248.4

Anti-Bovine Whole Serum | RWS-10
RWS-10	Immunology Consultants Laboratory	1.0 mL	EUR 130
Description: Anti-Bovine Whole Serum | RWS-10 | Immunology Consultants Laboratory Host: Rabbit Format: Whole Serum Product Type: Primary Antibody Antibody Clonality: Polyclonal

Neptune Barrier tip 10ul Extended Length Filter Tip
BT10XL	Biotix	10 trays of 96 / pack	EUR 70.8
Description: 10ul extended length barrier tip. Racked, Pre-Sterile, Natural Polypropylene.

Mouse serum albumin antigen grade (MSA) (>97%, low endotoxin, low fatty acid, mouse viruses tested)
ALB14-N-10	Alpha Diagnostics	10 mg	EUR 489.6

10x17 cellogel 250µ (10)
EHCA1200-SH01-10	Consort	ea	EUR 67.2

10x17 cellogel 200µ (10)
EHCA1200-SH02-10	Consort	ea	EUR 67.2

10x17 cellogel 190µ (10)
EHCA1200-SH03-10	Consort	ea	EUR 67.2

10x17 cellogel 500µ (10)
EHCA1200-SH04-10	Consort	ea	EUR 82.8

16.5x14 cellogel 250µ (10)
EHCA1200-SH07-10	Consort	ea	EUR 82.8

16.5x14 cellogel 200µ (10)
EHCA1200-SH08-10	Consort	ea	EUR 82.8

16.5x14 cellogel 500µ (10)
EHCA1200-SH10-10	Consort	ea	EUR 93.6

17x17 cellogel 250µ (10)
EHCA1200-SH12-10	Consort	ea	EUR 104.4

17x17 cellogel 200µ (10)
EHCA1200-SH13-10	Consort	ea	EUR 104.4

17x17 cellogel 500µ (10)
EHCA1200-SH15-10	Consort	ea	EUR 126

20.5x20.5 cellogel 250µ (10)
EHCA1200-SH17-10	Consort	ea	EUR 256.8

20.5x20.5 cellogel 200µ (10)
EHCA1200-SH18-10	Consort	ea	EUR 256.8

20.5x20.5 cellogel 500µ (10)
EHCA1200-SH20-10	Consort	ea	EUR 312

30x30 cellogel 250µ (10)
EHCA1200-SH22-10	Consort	ea	EUR 519.6

30x30 cellogel 200µ (10)
EHCA1200-SH23-10	Consort	ea	EUR 519.6

30x30 cellogel 500µ (10)
EHCA1200-SH25-10	Consort	ea	EUR 595.2

18.3x14 cellogel 200µ (10)
EHCA1200-SH28-10	Consort	ea	EUR 169.2

18.3x17 cellogel 250µ (10)
EHCA1200-SH33-10	Consort	ea	EUR 202.8

10 nm DOPC Nanodisc
ND-OCGS-10	ProFoldin	90 mg	EUR 282.18
Description: This product includes 2 ml of 5 mg/ml lipids composed of DOPC:Cholesterol: DSPE-PEG2000 and 40 mg/ml SMA copolymer 3:1 in 0.1 M TrisHCl, pH 7.6.

AXYGEN® GEL TRAY 10 X 10 CM FOR USE WITH 10 CM GEL BOX, UV TRANSPARENT
HGB10-10-GT	CORNING	1/pk	EUR 88.8
Description: Lab Equipment; Axygen Branded EQ

Human Exosome lysate positive protein control (10ug/ul), Size 50 ul
EXOAB-POS-1	SBI	500 ug	EUR 427.2

Mouse Anti Bovine Interleukin-10 Monoclonal Antibody,Low Endotoxin
CABT-48529MB	Creative Diagnostics	0.5 mg	EUR 1033.2

Positive displacement micropipette Acura capillar 846 volume 10 - 20 - 30 - 40 - 50 uL
DD61947	Scientific Laboratory Supplies	EACH	EUR 373.92

DiagNano Silica-Coated Gold Nanoparticles, 10 nm
CG-10	Creative Diagnostics	10mL	EUR 862.8

Ethyl-β-D-glucuronide-d5, 10 mg
0901D-10	AthenaES	10 mg	EUR 1874.4

Ethyl sulfate-d5, sodium salt, 10 mg
0902D-10	AthenaES	10 mg	EUR 292.8

2-Propyl-β-D-glucuronide, 10 mg
0904-10	AthenaES	10 mg	EUR 664.8

Ethyl-β-D-glucuronide-13C6, 10 mg
0905-10	AthenaES	10 mg	EUR 1767.6

AXYGEN® HORIZONTAL GEL BOX, 10 CM
HGB-10	CORNING	1/pk	EUR 399.6
Description: Lab Equipment; Axygen Branded EQ

DiagNano Fluorophore Labeled Gold Nanoparticles, 10 nm
GFL-10	Creative Diagnostics	1 mL	EUR 1263.6

CXCL10/IP-10/CRG-2, human recombinant
4277-10	Biovision	each	EUR 222

Anti-Bovine Albumin (BSA) Antibody | RAL-10
RAL-10	Immunology Consultants Laboratory	1.0 mL	EUR 141
Description: Anti-Bovine Albumin (BSA) Antibody | RAL-10 | Immunology Consultants Laboratory Host: Rabbit Format: Whole Serum Product Type: Primary Antibody Antibody Clonality: Polyclonal

DiaEasy? Dialyzer (10 ml) MWCO 3.5 kDa
K1002-10	Biovision	each	EUR 216

DiaEasy? Dialyzer (10 ml) MWCO 1 kDa
K1011-10	Biovision	each	EUR 438

INTELLI-PLATE 96-2 low profile
MAR-102-0001-10	MiTeGen	120 PLATES	EUR 990
Description: INTELLI-PLATE 96-2 low profile;  2-well sitting drop, 120 plates

Asymmetrical Mixer Union for LCP. Couples to 250 uL syringes on one side and to 250 uL, 50 uL, or 100 uL syringes on the other.
MLCP-AMXU-1	MiTeGen	1 UNIT	EUR 180
Description: Asymmetrical Mixer Union for LCP. Couples to 250 uL syringes on one side and to 250 uL, 50 uL, or 100 uL syringes on the other.

16.5x14 cellogel 190µ hr (10)
EHCA1200-SH09-10	Consort	ea	EUR 82.8

17x17 cellogel 190µ hr (10)
EHCA1200-SH14-10	Consort	ea	EUR 104.4

20.5x20.5 cellogel 190µ hr (10)
EHCA1200-SH19-10	Consort	ea	EUR 256.8

30x30 cellogel 190µ hr (10)
EHCA1200-SH24-10	Consort	ea	EUR 519.6

18.3x14 cellogel 190µ hr (10)
EHCA1200-SH27-10	Consort	ea	EUR 169.2

18.3x17 cellogel 190µ hr (10)
EHCA1200-SH32-10	Consort	ea	EUR 202.8

Turbidity Std Ratio 10 NTU
CRSR-10-100	Scientific Laboratory Supplies	100ML	EUR 125.4

Turbidity Std Ratio 10 NTU
CRSR-10-500	Scientific Laboratory Supplies	500ML	EUR 248.52

Graduated tip 1000uL fine tip in refill ESP NEPTUNE
DD712160B	Scientific Laboratory Supplies	PK960	EUR 30.78

Tsg DNA Polymerase, 5u/ul
D0081	Bio Basic	5X200U	EUR 112.2

Tsg PlusDNA Polymerase, 5u/ul
D0088	Bio Basic	200U	EUR 94.8

AMV Reverse Transcriptase, 10u/ul
A1201-200	GenDepot	200 units	EUR 267.6

AMV Reverse Transcriptase, 10u/ul
A1201-500	GenDepot	500 units	EUR 481.2

T4 Endonuclease V, 5u/ul
BEN0141	Bio Basic	250U	EUR 185.28

DNA Polymerase I, 10u/ul
BEP0041	Bio Basic	500U	EUR 128.9

T4 DNA Polymerase, 5u/ul
BEP0061	Bio Basic	100U	EUR 153.97

PHI29 DNA Polymerase, 10u/ul
BEP0091	Bio Basic	250U	EUR 187.37

PHI29 DNA Polymerase, 10u/ul
BEP0092	Bio Basic	1KU	EUR 561.12

Taq DNA Polymerase, 5u/ul
B0089(D0089)	Bio Basic	5X200U	EUR 112.2

Pfu DNA Polymerase, 5u/ul
B0093(D0090P)	Bio Basic	500U	EUR 164.4

AMV Reverse Transcriptase, 10u/ul
B0999	Bio Basic	200U	EUR 143.52

T4 DNA Ligase, 5u/ul
B1122	Bio Basic	1KU	EUR 190.5

T4 DNA Ligase, 5u/ul
B1125	Bio Basic	200U	EUR 93.41

OZ Biosciences FLYFECTIN 500 uL
FF50500	Scientific Laboratory Supplies	EACH	EUR 167.58

AntiGST HRP Conjugate 75 ul
RPN1236	Scientific Laboratory Supplies	EACH	EUR 295.26

Oz Biosciences ProDeliverIN 250 ul
PI10250	Scientific Laboratory Supplies	EACH	EUR 409.26

Oz Biosciences Combimag 200 ul
CM20200	Scientific Laboratory Supplies	EACH	EUR 121.98

Oz Biosciences ViroMag 200 ul
VM40200	Scientific Laboratory Supplies	EACH	EUR 186.96

NEPTUNE BarriersTips ,10 ul Low Retentio