MK-5 with vented cover (polycarbonate
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 MK 886 |
|
B6684-5 |
ApexBio |
5 mg |
EUR 137 |
 MK 571 |
|
B7023-5 |
ApexBio |
5 mg |
EUR 128 |
|
Description: MK 571 (L-660,711) is a novel potent and selective antagonist of leukotriene D4 receptor with Ki values of 0.22 nM and 2.1 nM in guinea pig and human lung membranes, respectively [1]. |
 MK-4101 |
|
B7803-5 |
ApexBio |
5 mg |
EUR 261 |
|
Description: IC50: 1.5 ?mol/L for in mouse Light II cells by Gli_luc assayMK-4101 is a Hedgehog (Hh) signaling pathway inhibitor.Abnormal activation of the Hedgehog (Hh) signaling pathway is reported in the pathogenesis of various cancers, such as medulloblastoma and basal cell carcinoma. |
 MK-0752 |
|
A4006-5 |
ApexBio |
5 mg |
EUR 247 |
|
Description: MK-0752 is a potent gamma secretase inhibitor in clinical development (IC50 ~50 nM). |
 MK-2048 |
|
A4072-5 |
ApexBio |
5 mg |
EUR 270 |
|
Description: MK-2048 is a second generation inhibitor of HIV-1 integrase with IC50 values of 0.075 ?M and 0.08 ?M for subtype B and subtype C integrase, respectively.Integration of viral cDNA into the host genome is one of the definitive features of retrovirus replication. |
 MK-8245 |
|
A4345-5 |
ApexBio |
5 mg |
EUR 268 |
|
Description: MK-8245 is a potent and liver-selective inhibitor of stearoyl-CoA desaturase (SCD) with IC50 value of 1nM [1].SCD1 represents a therapeutic target for the treatment of type II diabetes, dyslipidemia, obesity, and metabolic diseases. |
 MK-1775 |
|
A5755-5 |
ApexBio |
5 mg |
EUR 148 |
|
Description: MK-1775 is a potent and selective Wee1 inhibitor with an IC50 of 5.2 nM in a cell-free assay. MK-1775 abolishes cyclin-dependent kinase 1 (CDC2) activity by phosphorylation of the Tyr15 residue [1]. |
 MK-2461 |
|
A8476-5 |
ApexBio |
5 mg |
EUR 268 |
|
Description: MK-2461 is a potent inhibitor of Met, Flt1, Flt 3, Ron, PDGFR?, and Mer with IC50 of 2.5 nM, 10 nM, 22 nM, 7 nM, and 24 nM, respectively. |
 MK 6096 |
|
A8953-5 |
ApexBio |
5 mg |
EUR 321 |
|
Description: MK 6096 |
 MK 0893 |
|
A3608-5 |
ApexBio |
5 mg |
EUR 415 |
|
Description: MK 0893 is an inhibitor of both glucagon receptor and IGF-1R with IC50 values of 6.6nM and 6nM, respectively [1, 2]. |
 MK-0591 |
|
A3609-5 |
ApexBio |
5 mg |
EUR 284 |
|
Description: MK-0591, an analog of MK-886 is a potent and orally active leukotriene biosynthesis inhibitor with an IC50 value of 600 ng/ml. |
 MK-0812 |
|
A3611-5 |
ApexBio |
5 mg |
EUR 379 |
|
Description: MK-0812 is an antagonist of chemokine receptor CCR-2 [1].C-C chemokine receptor type 2 (CCR-2) is a chemokine receptor expressing on monocytes and macrophages and plays a critical and apparently non-redundant role in orchestrating the trafficking of monocytes to tissues [1]. |
 MK-0974 |
|
A3612-5 |
ApexBio |
5 mg |
EUR 395 |
|
Description: MK-0974 (Telcagepant) is a highly potent, selective, and orally bioavailable antagonist of CGRP receptor with IC50 value of 0.77 nM [1]. |
MK-5 with vented cover (polycarbonate
