MK-5 with vented cover (polycarbonate
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 MK 886 |
|
B6684-5 |
ApexBio |
5 mg |
EUR 137 |
 MK 571 |
|
B7023-5 |
ApexBio |
5 mg |
EUR 128 |
|
Description: MK 571 (L-660,711) is a novel potent and selective antagonist of leukotriene D4 receptor with Ki values of 0.22 nM and 2.1 nM in guinea pig and human lung membranes, respectively [1]. |
 MK-4101 |
|
B7803-5 |
ApexBio |
5 mg |
EUR 261 |
|
Description: IC50: 1.5 ?mol/L for in mouse Light II cells by Gli_luc assayMK-4101 is a Hedgehog (Hh) signaling pathway inhibitor.Abnormal activation of the Hedgehog (Hh) signaling pathway is reported in the pathogenesis of various cancers, such as medulloblastoma and basal cell carcinoma. |
 MK 0893 |
|
A3608-5 |
ApexBio |
5 mg |
EUR 415 |
|
Description: MK 0893 is an inhibitor of both glucagon receptor and IGF-1R with IC50 values of 6.6nM and 6nM, respectively [1, 2]. |
 MK-0591 |
|
A3609-5 |
ApexBio |
5 mg |
EUR 284 |
|
Description: MK-0591, an analog of MK-886 is a potent and orally active leukotriene biosynthesis inhibitor with an IC50 value of 600 ng/ml. |
 MK-0812 |
|
A3611-5 |
ApexBio |
5 mg |
EUR 379 |
|
Description: MK-0812 is an antagonist of chemokine receptor CCR-2 [1].C-C chemokine receptor type 2 (CCR-2) is a chemokine receptor expressing on monocytes and macrophages and plays a critical and apparently non-redundant role in orchestrating the trafficking of monocytes to tissues [1]. |
 MK-0974 |
|
A3612-5 |
ApexBio |
5 mg |
EUR 395 |
|
Description: MK-0974 (Telcagepant) is a highly potent, selective, and orally bioavailable antagonist of CGRP receptor with IC50 value of 0.77 nM [1]. |
 MK-2894 |
|
A3613-5 |
ApexBio |
5 mg |
EUR 357 |
|
Description: MK-2894 is a highly potent and selective inhibitor of EP4 receptor with IC50 value of 2.5 nM [1]. |
 MK-3207 |
|
A3615-5 |
ApexBio |
5 mg |
EUR 340 |
|
Description: MK-3207 is a new, highly selective CGRP receptor antagonist that is approximately 40- to 65-fold more potent than telcagepant for the human CGRP receptor. The IC50 is 0.12 nM and The Ki value is 0.024 nM. It is highly selective versus human AM1, AM2, CTR, and AMY3. |
 MK-4827 |
|
A3617-5 |
ApexBio |
5 mg |
EUR 209 |
|
Description: MK-4827 is a novel, selective and orally bioavailable PARP1/PARP2 inhibitor with IC50 of 3.8 nM and 2.1 nM, respevctively.MK-4827 has shown great activity against cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1 [1]. |
 MK-5172 |
|
A3618-5 |
ApexBio |
5 mg |
EUR 154 |
|
Description: MK-5172 is a selective inhibitor of Hepatitis C Virus NS3/4a Protease [1].Hepatitis C (HCV) virus is a member of the Flaviviridae family of viruses in the Hepacivirus genus and encoded by a 9.6-kb positive strand RNA genome [2]. |
 MK-6892 |
|
A3623-5 |
ApexBio |
5 mg |
EUR 502 |
|
Description: Description:IC50 Value: 4.0 nM (Ki for Human GPR109A) [1]MK-6892 is a highly potential GPR109A agonists.in vitro: . Despite the increased serum shift of these compounds, the representative 1e was highly potent |
 MK-8033 |
|
A3624-5 |
ApexBio |
5 mg |
EUR 466 |
|
Description: MK-8033 is a c-MET inhibitor in clinical trials. MK8033 is a selective small-molecule inhibitor, ATP competitive. Phase I investigation of the cMet inhibitor MK-8033 is ongoing. |
 MK-0752 |
|
A4006-5 |
ApexBio |
5 mg |
EUR 247 |
|
Description: MK-0752 is a potent gamma secretase inhibitor in clinical development (IC50 ~50 nM). |
 MK-2048 |
|
A4072-5 |
ApexBio |
5 mg |
EUR 270 |
|
Description: MK-2048 is a second generation inhibitor of HIV-1 integrase with IC50 values of 0.075 ?M and 0.08 ?M for subtype B and subtype C integrase, respectively.Integration of viral cDNA into the host genome is one of the definitive features of retrovirus replication. |
MK-5 with vented cover (polycarbonate
